DualControl™ panels are arranged in either overexpression/wild type, wild type/null and overexpression/null expression. Two cell lines contrasting in expression levels improve assessment capabilities. Referencing either no expression to wild type expression and wild type expression to overexpression maximizes assessment potential. These panels improve histology laboratory antibody optimization and pathologist IHC assessment. Currently, we offer p53 OE, P53 null, p16 OE, p16 null, RB null, p53R248Q, C-MYC amplification, PTEN deficiency, MLH-1, PMS-2, MSH-2, and MSH-6 DualControl™ panels in either FFPE block(s) or slide(s).